Exosomal miRNAs in Lung Diseases: From Biologic Function to Therapeutic Targets
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چکیده
منابع مشابه
Exosomal miRNAs as cancer biomarkers and therapeutic targets
Intercommunication between cancer cells and with their surrounding and distant environments is key to the survival, progression and metastasis of the tumour. Exosomes play a role in this communication process. MicroRNA (miRNA) expression is frequently dysregulated in tumour cells and can be reflected by distinct exosomal miRNA (ex-miRNA) profiles isolated from the bodily fluids of cancer patien...
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MicroRNAs (miRNAs), small non-coding regulatory RNAs that regulate gene expression at the post-transcriptional level, are master regulators of a wide array of cellular processes. Altered miRNA expression could be a determinant of disease development and/or progression and manipulation of miRNA expression represents a potential avenue of therapy. Exosomes are cell-derived extracellular vesicles ...
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MicroRNAs (miRNAs) represent a large family of small, nearly 20-22 nucleotide non-coding RNAs that modulate the expression of target genes, specially at the posttranscriptional level. Many studies suggest that miRNAs play a role in homeostatic preservation and that deviant expression of miRNAs is usually seen in several types of diseases, such as cancer. Exosomes are extracellular vesicles synt...
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Micro-RNAs (miRNAs) are small noncoding RNAs involved in the posttranscriptional regulation of gene expression. Exosomes have recently emerged as novel elements of intercellular communication in the cardiovascular system. Exosomal miRNAs could be key players in intercellular cross-talk, particularly during different diseases such as myocardial infarction (MI) and heart failure (HF). This review...
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The knowledge that miRNA expression is frequently dysregulated in cancer has uncovered an entirely new repertoire of molecular factors upstream of gene expression, with exciting potential as novel biomarkers and therapeutic targets in cancer. Exploiting the unique characteristics of these molecules including their stability, tissue specificity, ease of detection and manipulation, will bring cli...
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ژورنال
عنوان ژورنال: Journal of Clinical Medicine
سال: 2019
ISSN: 2077-0383
DOI: 10.3390/jcm8091345